Best bets: Advil Liqui-Gels. Also good: Bayer Aspirin Express (ASA granules that dissolve on your tongue). Liquid ibuprofen works 10 to 15 minutes faster than ibuprofen tablets, while rapidly absorbed ASA granules can be taken without water and go to work quickly. That’s helpful when each minute feels like an eternity, says Meek.
Take medication at the first sign of migraine—the longer you wait, the harder it is to relieve pain.
If OTC meds don’t work and your pain is more severe than usual, different, or accompanied by fever and vomiting, see your doctor.